Major Target Selection Strategies

Identification of targets with new folds

Grid technology-based high throughput screening of the publicly available genomes for identification of potential new folds using homology analysis using Blast; domain analysis using InterPro, Blocks and Chisel.

Identification of Essential genes to be used for the development of antibacterial agents.

1. Metabolic reconstructions from Sequence data.

2. Taxonomy Exclusive Enzyme Set.

3. Homology-based prediction of essential genes in B anthracis. 4. Essential genes in select pathogens

Characterization and annotation of the MCSG targets.

1. Characteriazation of MCSG targets using conventional (Blast, Blocks, TMHMM, etc) tools and TarGetDB specific tools (CHISEL, PUMA2, etc).

2. Connection of the MCSG targets to the metabolic pathways.

Identification of Pathogenicity Factors.

1. Pathogenicity factors from B. anthracis.

NEW: Updated Targets for B. anthracis Virulence Factors

2. Identification of pathogenicity factors in MCSG selected targets.